Become a devotee.
It’s impossible to understand everything. You simply cannot understand even one molecule of DNA, an elephant, or a leaf. All of this operates on a higher level of existential intelligence. And if you really see this, you become a devotee. You can be either an outsider of the life process or a devotee. Being a devotee puts your self-esteem in danger. However, both “self” and “esteem” are limited entities. They are fragile and both are problems. If you don’t have “esteem,” good. If you don’t have “self,” fabulous.